Analysis of shared heritability in common disorders of the brain
Brainstorm Consortium, V Anttila, B Bulik-Sullivan… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …
epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed …
Predictors of mortality in hospitalized COVID‐19 patients: a systematic review and meta‐analysis
Mortality rates of coronavirus disease‐2019 (COVID‐19) continue to rise across the world.
Information regarding the predictors of mortality in patients with COVID‐19 remains scarce …
Information regarding the predictors of mortality in patients with COVID‐19 remains scarce …
[HTML][HTML] Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies
Y Bykhovskaya, X Li, I Epifantseva… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: Keratoconus is a bilateral noninflammatory progressive corneal disorder with
complex genetic inheritance and a common cause for cornea transplantation in young …
complex genetic inheritance and a common cause for cornea transplantation in young …
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by
previous studies; however, a large portion of the genetic risk for this disease remains …
previous studies; however, a large portion of the genetic risk for this disease remains …
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …
association studies. To advance gene discovery further, we combined data from three …
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common,
chronic disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To …
chronic disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To …
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis …
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis …