Metabolomics for clinical use and research in chronic kidney disease
B Hocher, J Adamski - Nature Reviews Nephrology, 2017 - nature.com
Chronic kidney disease (CKD) has a high prevalence in the general population and is
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …
associated with high mortality; a need therefore exists for better biomarkers for diagnosis …
Integrated view on 17beta-hydroxysteroid dehydrogenases
G Moeller, J Adamski - Molecular and cellular endocrinology, 2009 - Elsevier
17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) are important enzymes in steroid
metabolism. Long known members of the protein family seemed to be well characterised …
metabolism. Long known members of the protein family seemed to be well characterised …
17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development
S Marchais-Oberwinkler, C Henn, G Möller… - The Journal of steroid …, 2011 - Elsevier
17β-Hydroxysteroid dehydrogenases (17β-HSDs) are oxidoreductases, which play a key
role in estrogen and androgen steroid metabolism by catalyzing final steps of the steroid …
role in estrogen and androgen steroid metabolism by catalyzing final steps of the steroid …
Human metabolic individuality in biomedical and pharmaceutical research
Genome-wide association studies (GWAS) have identified many risk loci for complex
diseases, but effect sizes are typically small and information on the underlying biological …
diseases, but effect sizes are typically small and information on the underlying biological …
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach
Metabolomic discovery of biomarkers of type 2 diabetes (T2D) risk may reveal etiological
pathways and help to identify individuals at risk for disease. We prospectively investigated …
pathways and help to identify individuals at risk for disease. We prospectively investigated …
[HTML][HTML] Tobacco smoking leads to extensive genome-wide changes in DNA methylation
S Zeilinger, B Kühnel, N Klopp, H Baurecht… - PloS one, 2013 - journals.plos.org
Environmental factors such as tobacco smoking may have long-lasting effects on DNA
methylation patterns, which might lead to changes in gene expression and in a broader …
methylation patterns, which might lead to changes in gene expression and in a broader …
[HTML][HTML] Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
C Gieger, L Geistlinger, E Altmaier… - PLoS …, 2008 - journals.plos.org
The rapidly evolving field of metabolomics aims at a comprehensive measurement of ideally
all endogenous metabolites in a cell or body fluid. It thereby provides a functional readout of …
all endogenous metabolites in a cell or body fluid. It thereby provides a functional readout of …
Novel biomarkers for pre‐diabetes identified by metabolomics
R Wang‐Sattler, Z Yu, C Herder… - Molecular systems …, 2012 - embopress.org
Type 2 diabetes (T2D) can be prevented in pre‐diabetic individuals with impaired glucose
tolerance (IGT). Here, we have used a metabolomics approach to identify candidate …
tolerance (IGT). Here, we have used a metabolomics approach to identify candidate …
[HTML][HTML] Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease
and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a …
and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a …
A genome-wide perspective of genetic variation in human metabolism
Serum metabolite concentrations provide a direct readout of biological processes in the
human body, and they are associated with disorders such as cardiovascular and metabolic …
human body, and they are associated with disorders such as cardiovascular and metabolic …