The first macrolide, erythromycin A, demonstrated broad-spectrum antimicrobial activity and
was used primarily for respiratory and skin and soft tissue infections. Newer 14-, 15-and 16 …

Foot ulcers are a common, serious, and costly complication of diabetes, preceding 84% of
lower extremity amputations in diabetic patients and increasing the risk of death by 2.4-fold …

Ketolides are a new class of macrolides designed particularly to combat respiratory tract
pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic …

Foot infections are a common and serious problem in persons with diabetes. Diabetic foot
infections (DFIs) typically begin in a wound, most often a neuropathic ulceration. While all …

1. Foot infections in patients with diabetes cause substantial morbidity and frequent visits to
health care professionals and may lead to amputation of a lower extremity. 2. Diabetic foot …

Abstract The International Working Group on the Diabetic Foot (IWGDF) has published
evidence‐based guidelines on the prevention and management of diabetic foot disease …

Clostridium difficile-associated diarrhea (CAD) is a very common nosocomial infection that
contributes significantly to patient morbidity and mortality as well as to the cost of …

Topically applied recombinant human platelet‐derived growth factor‐BB (becaplermin) is a
new pharmacologically active therapy for chronic, neuropathic, lower extremity diabetic …

OBJECTIVES:: To compare the effect of tigecycline monotherapy, a first-in-class, expanded
broad spectrum glycylcycline, with the combination of vancomycin and aztreonam (V+ A) in …

Numerous techniques for ankle arthrodesis have been reported since the original
description of compression arthrodesis. From the early 1950s to the mid 1970s, external …