Inflammation and the pathogenesis of diabetic nephropathy

J Wada, H Makino - Clinical science, 2013 - portlandpress.com
The most problematic issue in clinical nephrology is the relentless and progressive increase
in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic …

Diabetic nephropathy: mechanisms of renal disease progression

YS Kanwar, J Wada, L Sun, P Xie… - Experimental …, 2008 - journals.sagepub.com
Diabetic nephropathy is characterized by excessive amassing of extracellular matrix (ECM)
with thickening of glomerular and tubular basement membranes and increased amount of …

Innate immunity in diabetes and diabetic nephropathy

J Wada, H Makino - Nature Reviews Nephrology, 2016 - nature.com
The innate immune system includes several classes of pattern recognition receptors (PRRs),
including membrane-bound Toll-like receptors (TLRs) and nucleotide-binding …

Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity

K Hida, J Wada, J Eguchi, H Zhang… - Proceedings of the …, 2005 - National Acad Sciences
There is a rapid global rise in obesity, and the link between obesity and diabetes remains
somewhat obscure. We identified an adipocytokine, designated as visceral adipose tissue …

[HTML][HTML] Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db …

N Terami, D Ogawa, H Tachibana, T Hatanaka… - PloS one, 2014 - journals.plos.org
Inhibition of sodium glucose cotransporter 2 (SGLT2) has been reported as a new
therapeutic strategy for treating diabetes. However, the effect of SGLT2 inhibitors on the …

[HTML][HTML] Identification and characterization of galectin-9, a novel β-galactoside-binding mammalian lectin

J Wada, YS Kanwar - Journal of Biological Chemistry, 1997 - ASBMB
A 36-kDa β-galactoside mammalian lectin protein, designated as galectin-9, was isolated
from mouse embryonic kidney by using a degenerate primer polymerase chain reaction and …

Intercellular adhesion molecule-1–deficient mice are resistant against renal injury after induction of diabetes

S Okada, K Shikata, M Matsuda, D Ogawa, H Usui… - Diabetes, 2003 - Am Diabetes Assoc
Diabetic nephropathy is a leading cause of end-stage renal failure. Several mechanisms,
including activation of protein kinase C, advanced glycation end products, and …

[HTML][HTML] Variations in the FTO gene are associated with severe obesity in the Japanese

K Hotta, Y Nakata, T Matsuo, S Kamohara… - Journal of human …, 2008 - nature.com
Variations in the fat-mass and obesity-associated gene (FTO) are associated with the
obesity phenotype in many Caucasian populations. This association with the obesity …

Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.

J Wada, K Ota, A Kumar, EI Wallner… - The Journal of clinical …, 1997 - Am Soc Clin Investig
Galectin-9, a beta-galactoside binding lectin, has recently been isolated from murine
embryonic kidney. In this study, its biological functions and expression in embryonic …

Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice

M Suda, I Shimizu, G Katsuumi, Y Yoshida, Y Hayashi… - Nature Aging, 2021 - nature.com
Elimination of senescent cells (senolysis) was recently reported to improve normal and
pathological changes associated with aging in mice,. However, most senolytic agents inhibit …