Importance Metformin is widely viewed as the best initial pharmacological option to lower
glucose concentrations in patients with type 2 diabetes mellitus. However, the drug is …

Acommon clinical conundrum faces all US practitioners treating patients with type 2
diabetes. Today's US Food and Drug Administration prescribing guidelines for metformin …

Although cardiologists have long treated patients with coronary artery disease (CAD) and
concomitant type 2 diabetes mellitus (T2DM), T2DM has traditionally been considered just a …

Importance In older adults with multiple serious comorbidities and functional limitations, the
harms of intensive glycemic control likely exceed the benefits. Objectives To examine …

Importance The increasing intensity of diabetes mellitus management over the past decade
may have resulted in lower rates of hyperglycemic emergencies but higher rates of hospital …

OBJECTIVE To examine temporal trends in utilization of glucose-lowering medications,
glycemic control, and rate of severe hypoglycemia among patients with type 2 diabetes …

OBJECTIVE We examined the association between HbA1c level and self-reported severe
hypoglycemia in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Type …

Importance There is substantial uncertainty about optimal glycemic control in older adults
with type 2 diabetes mellitus. Observations Four large randomized clinical trials (RCTs) …

Methods| We administered a survey to patients with type 1 or type 2 diabetes for whom
insulin was prescribed within the past 6 months and who had an outpatient visit at the Yale …

Easier to measure surrogate outcomes are often used instead of patient important outcomes
such as death, quality of life, or functional capacity when assessing treatments. John Yudkin …