User profiles for "author:Kathrin Brockmann"
Kathrin BrockmannUniversity of Tuebingen, Hertie Institute for Clinical Brain Research, DZNE Verified email at uni-tuebingen.de Cited by 10299 |
Cognitive changes in prodromal Parkinson's disease: a review
S Fengler, I Liepelt‐Scarfone, K Brockmann… - Movement …, 2017 - Wiley Online Library
Although other nonmotor phenomena representing possible prodromal symptoms of
Parkinson's disease have been described in some detail, the occurrence and characteristics …
Parkinson's disease have been described in some detail, the occurrence and characteristics …
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
MA Nalls, C Blauwendraat, CL Vallerga… - The Lancet …, 2019 - thelancet.com
Background Genome-wide association studies (GWAS) in Parkinson's disease have
increased the scope of biological knowledge about the disease over the past decade. We …
increased the scope of biological knowledge about the disease over the past decade. We …
[HTML][HTML] GBA-associated PD: chances and obstacles for targeted treatment strategies
Given the clear role of GBA in the pathogenesis of Parkinson's disease (PD) and its impact
on phenotypical characteristics, this review provides an overview of the current knowledge …
on phenotypical characteristics, this review provides an overview of the current knowledge …
[PDF][PDF] Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression
P Reinhardt, B Schmid, LF Burbulla, DC Schöndorf… - Cell stem cell, 2013 - cell.com
Summary The LRRK2 mutation G2019S is the most common genetic cause of Parkinson's
disease (PD). To better understand the link between mutant LRRK2 and PD pathology, we …
disease (PD). To better understand the link between mutant LRRK2 and PD pathology, we …
A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies
MA Nalls, R Duran, G Lopez, M Kurzawa-Akanbi… - JAMA …, 2013 - jamanetwork.com
Importance While mutations in glucocerebrosidase (GBA1) are associated with an increased
risk for Parkinson disease (PD), it is important to establish whether such mutations are also a …
risk for Parkinson disease (PD), it is important to establish whether such mutations are also a …
[PDF][PDF] Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-dependent mitophagy
S Lesage, V Drouet, E Majounie, V Deramecourt… - The American Journal of …, 2016 - cell.com
Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
A Beilina, IN Rudenko, A Kaganovich… - Proceedings of the …, 2014 - National Acad Sciences
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD),
and common variants around LRRK2 are a risk factor for sporadic PD. Using protein–protein …
and common variants around LRRK2 are a risk factor for sporadic PD. Using protein–protein …
[HTML][HTML] Blood and cerebrospinal fluid biomarkers of inflammation in Parkinson's disease
M Zimmermann, K Brockmann - Journal of Parkinson's …, 2022 - content.iospress.com
Given the clear role of inflammation in the pathogenesis of Parkinson's disease (PD) and its
impact on incidence and phenotypical characteristics, this review provides an overview with …
impact on incidence and phenotypical characteristics, this review provides an overview with …
GBA‐associated Parkinson's disease: Reduced survival and more rapid progression in a prospective longitudinal study
K Brockmann, K Srulijes, S Pflederer… - Movement …, 2015 - Wiley Online Library
Background Parkinson's disease (PD) patients with GBA mutations show an earlier age at
onset and more severe non‐motor symptoms compared with PD patients without GBA …
onset and more severe non‐motor symptoms compared with PD patients without GBA …
Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets
Importance Substantial genome-wide association study (GWAS) work in Parkinson disease
(PD) has led to the discovery of an increasing number of loci shown reliably to be associated …
(PD) has led to the discovery of an increasing number of loci shown reliably to be associated …