User profiles for "author:Kathrin Brockmann"

Kathrin Brockmann

University of Tuebingen, Hertie Institute for Clinical Brain Research, DZNE
Verified email at uni-tuebingen.de
Cited by 10299

Cognitive changes in prodromal Parkinson's disease: a review

S Fengler, I Liepelt‐Scarfone, K Brockmann… - Movement …, 2017 - Wiley Online Library
Although other nonmotor phenomena representing possible prodromal symptoms of
Parkinson's disease have been described in some detail, the occurrence and characteristics …

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

MA Nalls, C Blauwendraat, CL Vallerga… - The Lancet …, 2019 - thelancet.com
Background Genome-wide association studies (GWAS) in Parkinson's disease have
increased the scope of biological knowledge about the disease over the past decade. We …

[HTML][HTML] GBA-associated PD: chances and obstacles for targeted treatment strategies

G Höglinger, C Schulte, WH Jost, A Storch… - Journal of Neural …, 2022 - Springer
Given the clear role of GBA in the pathogenesis of Parkinson's disease (PD) and its impact
on phenotypical characteristics, this review provides an overview of the current knowledge …

[PDF][PDF] Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression

P Reinhardt, B Schmid, LF Burbulla, DC Schöndorf… - Cell stem cell, 2013 - cell.com
Summary The LRRK2 mutation G2019S is the most common genetic cause of Parkinson's
disease (PD). To better understand the link between mutant LRRK2 and PD pathology, we …

A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies

MA Nalls, R Duran, G Lopez, M Kurzawa-Akanbi… - JAMA …, 2013 - jamanetwork.com
Importance While mutations in glucocerebrosidase (GBA1) are associated with an increased
risk for Parkinson disease (PD), it is important to establish whether such mutations are also a …

[PDF][PDF] Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-dependent mitophagy

S Lesage, V Drouet, E Majounie, V Deramecourt… - The American Journal of …, 2016 - cell.com
Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

A Beilina, IN Rudenko, A Kaganovich… - Proceedings of the …, 2014 - National Acad Sciences
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD),
and common variants around LRRK2 are a risk factor for sporadic PD. Using protein–protein …

[HTML][HTML] Blood and cerebrospinal fluid biomarkers of inflammation in Parkinson's disease

M Zimmermann, K Brockmann - Journal of Parkinson's …, 2022 - content.iospress.com
Given the clear role of inflammation in the pathogenesis of Parkinson's disease (PD) and its
impact on incidence and phenotypical characteristics, this review provides an overview with …

GBA‐associated Parkinson's disease: Reduced survival and more rapid progression in a prospective longitudinal study

K Brockmann, K Srulijes, S Pflederer… - Movement …, 2015 - Wiley Online Library
Background Parkinson's disease (PD) patients with GBA mutations show an earlier age at
onset and more severe non‐motor symptoms compared with PD patients without GBA …

Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets

DA Kia, D Zhang, S Guelfi, C Manzoni… - JAMA …, 2021 - jamanetwork.com
Importance Substantial genome-wide association study (GWAS) work in Parkinson disease
(PD) has led to the discovery of an increasing number of loci shown reliably to be associated …