Background Several studies reported a U-shaped association between urinary sodium
excretion and cardiovascular disease events and mortality. Whether these associations vary …

Background Long-term aspirin prevents vascular events but is only modestly effective.
Rivaroxaban alone or in combination with aspirin might be more effective than aspirin alone …

Background The contribution of various risk factors to the burden of stroke worldwide is
unknown, particularly in countries of low and middle income. We aimed to establish the …

Background Global estimates of the effect of common modifiable risk factors on
cardiovascular disease and mortality are largely based on data from separate studies, using …

Background We evaluated whether rivaroxaban alone or in combination with aspirin would
be more effective than aspirin alone for secondary cardiovascular prevention. Methods In …

Background Stroke is a leading cause of death and disability, especially in low-income and
middle-income countries. We sought to quantify the importance of potentially modifiable risk …

Background Reduced muscular strength, as measured by grip strength, has been
associated with an increased risk of all-cause and cardiovascular mortality. Grip strength is …

Background Although most cardiovascular disease occurs in low-income and middle-
income countries, little is known about the use of effective secondary prevention medications …

Background More than 80% of deaths from cardiovascular disease are estimated to occur in
low-income and middle-income countries, but the reasons are unknown. Methods We …

Background The optimal range of sodium intake for cardiovascular health is controversial.
Methods We obtained morning fasting urine samples from 101,945 persons in 17 countries …