Monocytes and macrophages provide defence against pathogens and danger signals.
These cells respond to stimulation in a fast and stimulus-specific manner by utilizing …

Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …

Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but
how systemic metabolism influences immune cell metabolism and function remains to be …

Rationale: Patients with elevated levels of lipoprotein (a)[Lp (a)] are hallmarked by
increased metabolic activity in the arterial wall on positron emission tomography/computed …

Macrophages represent a major immune cell population in atherosclerotic plaques and play
central role in the progression of this lipid-driven chronic inflammatory disease. Targeting …

In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused
to> 60 different partner genes. In order to define a core set of MLL rearranged targets, we …

Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies
showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 signaling axis …

Atherosclerosis is a lipid-driven chronic inflammatory disease; however, whether it can be
classified as an autoimmune disease remains unclear. In this study, we applied single-cell T …

Abstract Aims Elevated lipoprotein (a)[Lp (a)] is strongly associated with an increased
cardiovascular disease (CVD) risk. We previously reported that pro-inflammatory activation …

Aims Genome-wide association studies (GWASs) have discovered hundreds of common
genetic variants for atherosclerotic disease and cardiovascular risk factors. The translation of …