Common variants associated with plasma triglycerides and risk for coronary artery disease

R Do, CJ Willer, EM Schmidt, S Sengupta, C Gao… - Nature …, 2013 - nature.com
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary …

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

DIAbetes Genetics Replication And Meta-analysis … - Nature …, 2014 - nature.com
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS) …

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

JS Kooner, D Saleheen, X Sim, J Sehmi, W Zhang… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

P Zanoni, SA Khetarpal, DB Larach… - Science, 2016 - science.org
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL)
cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a …

[HTML][HTML] Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians

H Li, TO Kilpeläinen, C Liu, J Zhu, Y Liu, C Hu, Z Yang… - Diabetologia, 2012 - Springer
Aims/hypothesis FTO harbours the strongest known obesity-susceptibility locus in
Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its …

Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India

R Saxena, D Saleheen, LF Been, ML Garavito… - Diabetes, 2013 - Am Diabetes Assoc
We performed a genome-wide association study (GWAS) and a multistage meta-analysis of
type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals …

Platelet inhibition with cangrelor and crushed ticagrelor in patients with ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary …

F Franchi, F Rollini, A Rivas, M Wali, M Briceno… - Circulation, 2019 - Am Heart Assoc
Background: The platelet inhibitory effects induced by oral P2Y12 receptor antagonists are
delayed in patients with ST-segment–elevation myocardial infarction undergoing primary …

Pharmacodynamic comparison of prasugrel versus ticagrelor in patients with type 2 diabetes mellitus and coronary artery disease: the OPTIMUS (Optimizing …

F Franchi, F Rollini, N Aggarwal, J Hu, M Kureti… - Circulation, 2016 - Am Heart Assoc
Background: Patients with diabetes mellitus (DM) are at increased risk of atherothrombotic
events, underscoring the importance of effective platelet inhibiting therapies. Prasugrel and …

PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor

DK Sanghera, FY Demirci, L Been, L Ortega, S Ralhan… - Metabolism, 2010 - Elsevier
We have examined the association of 14 tagging single nucleotide polymorphisms
(tagSNPs) in peroxisome proliferator activated receptor–γ transcripts 1 and 2 (PPARG1 and …

[HTML][HTML] A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23. 3 harbors loci contributing to triglycerides

TR Braun, LF Been, A Singhal, J Worsham, S Ralhan… - PloS one, 2012 - journals.plos.org
Recent genome-wide association scans (GWAS) and meta-analysis studies on European
populations have identified many genes previously implicated in lipid regulation. Validation …