User profiles for "author:Mandeep Bajaj"

Mandeep Bajaj

Professor of Medicine and Molecular and Cellular Biology, Baylor College of Medicine
Verified email at bcm.edu
Cited by 7537

Metabolic and molecular basis of insulin resistance

M Bajaj, RA DeFronzo - Journal of nuclear cardiology, 2003 - Springer
After an overnight fast (postabsorptive state), the majority of total body glucose utilization
takes place in insulin-dependent tissues. 1 Under basal conditions, approximately 50% of all …

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

S Kashyap, R Belfort, A Gastaldelli, T Pratipanawatr… - Diabetes, 2003 - Am Diabetes Assoc
Acute elevations in free fatty acids (FFAs) stimulate insulin secretion, but prolonged lipid
exposure impairs β-cell function in both in vitro studies and in vivo animal studies. In …

Adiponectin and vulnerable atherosclerotic plaques

A Barseghian, D Gawande, M Bajaj - Journal of the American College of …, 2011 - jacc.org
High-risk plaques that are vulnerable to rupture demonstrate distinct morphological
characteristics. They are differentiated from the lesions responsible for stable coronary artery …

Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients

M Bajaj, S Suraamornkul, P Piper… - The journal of …, 2004 - academic.oup.com
The effect of pioglitazone (PIO) on plasma adiponectin concentration, endogenous glucose
production (EGP), and hepatic fat content (HFC) was studied in 11 type 2 diabetic patients …

Type 2 diabetes in South Asians: a pathophysiologic focus on the Asian-Indian epidemic

M Bajaj, MA Banerji - Current diabetes reports, 2004 - Springer
There is a high prevalence of type 2 diabetes mellitus and coronary artery disease among
urban and migrant Asian Indians, despite the absence of traditional risk factors. Evidence …

SGLT-2 inhibition with dapagliflozin reduces the activation of the Nlrp3/ASC inflammasome and attenuates the development of diabetic cardiomyopathy in mice with …

Y Ye, M Bajaj, HC Yang, JR Perez-Polo… - … drugs and therapy, 2017 - Springer
Purpose We assessed whether (1) dapagliflozin (Dapa, an SGLT2-inhibitor) attenuates the
deterioration of heart function Nlrp3 and inflammasome activation in diabetic mice.(2) The …

Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes

M Bajaj, S Suraamornkul, T Pratipanawatr… - Diabetes, 2003 - Am Diabetes Assoc
The effect of pioglitazone on splanchnic glucose uptake (SGU), endogenous glucose
production (EGP), and hepatic fat content was studied in 14 type 2 diabetic patients (age …

[HTML][HTML] Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human …

DK Richardson, S Kashyap, M Bajaj, K Cusi… - Journal of Biological …, 2005 - ASBMB
The association between elevated plasma free fatty acid (FFA) concentrations and insulin
resistance is well known. Although the cause and effect relationship between FFAs and …

Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients

Y Miyazaki, A Mahankali, E Wajcberg… - The Journal of …, 2004 - academic.oup.com
We examined the effect of pioglitazone (PIO) on circulating adipocytokine levels to elucidate
the mechanisms by which thiazolidinediones improve insulin resistance in type 2 diabetes …

Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients

M Bajaj, S Suraamornkul, A Romanelli, GW Cline… - Diabetes, 2005 - Am Diabetes Assoc
To investigate the effect of a sustained (7-day) decrease in plasma free fatty acid (FFA)
concentrations on insulin action and intramyocellular long-chain fatty acyl-CoAs (LCFA …