[HTML][HTML] Role of inflammatory cytokines, growth factors and adipokines in adipogenesis and insulin resistance
Obesity, manifested by increased adiposity, represents a main cause of morbidity in the
developed countries, causing increased risk of insulin resistance and type 2 diabetes …
developed countries, causing increased risk of insulin resistance and type 2 diabetes …
[HTML][HTML] The impact of acute and chronic exercise on immunoglobulins and cytokines in elderly: insights from a critical review of the literature
M Sellami, NL Bragazzi, B Aboghaba… - Frontiers in …, 2021 - frontiersin.org
The level of immunoglobulins and cytokines changes with an ageing immune system. This
review summarizes findings from studies that have examined the impact of acute and …
review summarizes findings from studies that have examined the impact of acute and …
[HTML][HTML] Statistical methods and resources for biomarker discovery using metabolomics
Metabolomics is a dynamic tool for elucidating biochemical changes in human health and
disease. Metabolic profiles provide a close insight into physiological states and are highly …
disease. Metabolic profiles provide a close insight into physiological states and are highly …
[HTML][HTML] SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways
The NAD+-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating
target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or …
target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or …
[HTML][HTML] Metabolic signature of obesity-associated insulin resistance and type 2 diabetes
H Al-Sulaiti, I Diboun, MV Agha, FFS Mohamed… - Journal of translational …, 2019 - Springer
Background Obesity is associated with an increased risk of insulin resistance and type 2
diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity …
diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity …
[HTML][HTML] A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines
Background The outstanding performance of an elite athlete might be associated with
changes in their blood metabolic profile. The aims of this study were to compare the blood …
changes in their blood metabolic profile. The aims of this study were to compare the blood …
[HTML][HTML] Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance
S Almuraikhy, W Kafienah, M Bashah, I Diboun… - Diabetologia, 2016 - Springer
Aims/hypothesis A subset of obese individuals remains insulin sensitive by mechanisms as
yet unclear. The hypothesis that maintenance of normal subcutaneous (SC) adipogenesis …
yet unclear. The hypothesis that maintenance of normal subcutaneous (SC) adipogenesis …
[HTML][HTML] Genome-wide association study reveals a novel association between MYBPC3 gene polymorphism, endurance athlete status, aerobic capacity and steroid …
Background The genetic predisposition to elite athletic performance has been a
controversial subject due to the underpowered studies and the small effect size of identified …
controversial subject due to the underpowered studies and the small effect size of identified …
[HTML][HTML] Triglyceride profiling in adipose tissues from obese insulin sensitive, insulin resistant and type 2 diabetes mellitus individuals
H Al-Sulaiti, I Diboun, S Banu, M Al-Emadi… - Journal of translational …, 2018 - Springer
Background Lipid intermediates produced during triacylglycerols (TAGs) synthesis and
lipolysis in adipocytes interfere with the intracellular insulin signaling pathway and …
lipolysis in adipocytes interfere with the intracellular insulin signaling pathway and …
[HTML][HTML] Impact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug …
I Khan, R Needham, S Yousaf, C Houacine… - Journal of Drug Delivery …, 2021 - Elsevier
The aim of this study is to formulate and optimize novel transfersome formulations for
pulmonary drug delivery. Transfersome formulations (F1–F18) were prepared by a thin-film …
pulmonary drug delivery. Transfersome formulations (F1–F18) were prepared by a thin-film …