[HTML][HTML] Role of inflammatory cytokines, growth factors and adipokines in adipogenesis and insulin resistance

L Al-Mansoori, H Al-Jaber, MS Prince, MA Elrayess - Inflammation, 2022 - Springer
Obesity, manifested by increased adiposity, represents a main cause of morbidity in the
developed countries, causing increased risk of insulin resistance and type 2 diabetes …

[HTML][HTML] The impact of acute and chronic exercise on immunoglobulins and cytokines in elderly: insights from a critical review of the literature

M Sellami, NL Bragazzi, B Aboghaba… - Frontiers in …, 2021 - frontiersin.org
The level of immunoglobulins and cytokines changes with an ageing immune system. This
review summarizes findings from studies that have examined the impact of acute and …

[HTML][HTML] Statistical methods and resources for biomarker discovery using metabolomics

NR Anwardeen, I Diboun, Y Mokrab, AA Althani… - BMC …, 2023 - Springer
Metabolomics is a dynamic tool for elucidating biochemical changes in human health and
disease. Metabolic profiles provide a close insight into physiological states and are highly …

[HTML][HTML] SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways

Y Majeed, N Halabi, AY Madani, R Engelke… - Scientific reports, 2021 - nature.com
The NAD+-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating
target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or …

[HTML][HTML] Metabolic signature of obesity-associated insulin resistance and type 2 diabetes

H Al-Sulaiti, I Diboun, MV Agha, FFS Mohamed… - Journal of translational …, 2019 - Springer
Background Obesity is associated with an increased risk of insulin resistance and type 2
diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity …

[HTML][HTML] A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines

F Al-Khelaifi, I Diboun, F Donati, F Botrč… - Sports medicine …, 2018 - Springer
Background The outstanding performance of an elite athlete might be associated with
changes in their blood metabolic profile. The aims of this study were to compare the blood …

[HTML][HTML] Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance

S Almuraikhy, W Kafienah, M Bashah, I Diboun… - Diabetologia, 2016 - Springer
Aims/hypothesis A subset of obese individuals remains insulin sensitive by mechanisms as
yet unclear. The hypothesis that maintenance of normal subcutaneous (SC) adipogenesis …

[HTML][HTML] Genome-wide association study reveals a novel association between MYBPC3 gene polymorphism, endurance athlete status, aerobic capacity and steroid …

F Al-Khelaifi, NA Yousri, I Diboun, EA Semenova… - Frontiers in …, 2020 - frontiersin.org
Background The genetic predisposition to elite athletic performance has been a
controversial subject due to the underpowered studies and the small effect size of identified …

[HTML][HTML] Triglyceride profiling in adipose tissues from obese insulin sensitive, insulin resistant and type 2 diabetes mellitus individuals

H Al-Sulaiti, I Diboun, S Banu, M Al-Emadi… - Journal of translational …, 2018 - Springer
Background Lipid intermediates produced during triacylglycerols (TAGs) synthesis and
lipolysis in adipocytes interfere with the intracellular insulin signaling pathway and …

[HTML][HTML] Impact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug …

I Khan, R Needham, S Yousaf, C Houacine… - Journal of Drug Delivery …, 2021 - Elsevier
The aim of this study is to formulate and optimize novel transfersome formulations for
pulmonary drug delivery. Transfersome formulations (F1–F18) were prepared by a thin-film …