Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

S Kajiyama, G Hasegawa, M Asano, H Hosoda… - Nutrition Research, 2008 - Elsevier
Oxidative stress is recognized widely as being associated with various disorders including
diabetes, hypertension, and atherosclerosis. It is well established that hydrogen has a …

A meta-analysis of remote patient monitoring for chronic heart failure patients

N Nakamura, T Koga, H Iseki - Journal of telemedicine and …, 2014 - journals.sagepub.com
We carried out a meta analysis of remote patient monitoring (RPM) for chronic heart failure
(CHF) patients. A literature search was used to identify randomised controlled trials with …

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

K Yasuda, K Miyake, Y Horikawa, K Hara, H Osawa… - Nature …, 2008 - nature.com
We carried out a multistage genome-wide association study of type 2 diabetes mellitus in
Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The …

Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice

Y Naito, K Uchiyama, W Aoi, G Hasegawa… - …, 2004 - content.iospress.com
Oxidative stress is implicated as an important mechanism by which diabetes causes
nephropathy. Astaxanthin, which is found as a common pigment in algae, fish, and birds, is a …

Astaxanthin protects β-cells against glucose toxicity in diabetic db/db mice

K Uchiyama, Y Naito, G Hasegawa, N Nakamura… - Redox …, 2002 - Taylor & Francis
Oxidative stress induced by hyperglycemia possibly causes the dysfunction of pancreatic β-
cells and various forms of tissue damage in patients with diabetes mellitus. Astaxanthin, a …

Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease

H Park, T Shima, K Yamaguchi, H Mitsuyoshi… - Journal of …, 2011 - Springer
Background Hyperlipidemia, insulin resistance, and oxidative stress can heavily contribute
to the initiation and progression of nonalcoholic fatty liver disease (NAFLD). Currently, there …

Serum uric acid is associated with microalbuminuria and subclinical atherosclerosis in men with type 2 diabetes mellitus

M Fukui, M Tanaka, E Shiraishi, I Harusato, H Hosoda… - Metabolism, 2008 - Elsevier
Hyperuricemia has been reported to be associated with increased risk of renal insufficiency
as well as cardiovascular events. The aim of this study was to evaluate the relationships …

Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: relationship to glucose metabolism and biomarkers of insulin resistance

A Fujinami, K Ohta, H Obayashi, M Fukui… - Clinical …, 2008 - Elsevier
OBJECTIVES: The aims of this study were to measure serum levels of brain-derived
neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to …

Enzyme-linked immunosorbent assay for circulating human resistin: resistin concentrations in normal subjects and patients with type 2 diabetes

A Fujinami, H Obayashi, K Ohta, T Ichimura… - Clinica chimica acta, 2004 - Elsevier
Background: Resistin is a recently identified adipocyte-secreted hormone in rodents, and
has been proposed to serve as a link between obesity and insulin resistance. The aim of this …

Metabolically healthy obesity and risk of incident CKD

Y Hashimoto, M Tanaka, H Okada… - Clinical journal of the …, 2015 - journals.lww.com
Results The crude incidence proportions of CKD were 2.6%(56 of 2122 participants) in
participants with the metabolically healthy nonobesity phenotype, 2.6%(8 of 302) in those …