Substance use disorder (SUD) is a chronic condition, with maintained abuse of a substance
leading to physiological and psychological alterations and often changes in cognitive and …

Phenotyping of Gprc6a KO mice has shown that this promiscuous class CG protein coupled
receptor is variously involved in regulation of metabolism, inflammation and endocrine …

Osteoporosis is a progressive bone disorder characterised by imbalance between bone
building (anabolism) and resorption (catabolism). Most therapeutics target inhibition of …

Abstract Background and Purpose Strontium ranelate, a drug approved and until recently
used for the treatment of osteoporosis, mediates its effects on bone at least in part via the …

Relaxin, an emerging pharmaceutical treatment for acute heart failure, activates the relaxin
family peptide receptor (RXFP1), which is a class A G-protein-coupled receptor. In addition …

Background This study aimed to investigate clinicopathological and molecular tumour
features associated with intratumoral pks+ Escherichia coli (pks+ E. coli+), pks+ E. coli-(non …

The human histamine H3 receptor (hH3R) is subject to extensive gene splicing that gives
rise to a large number of functional and nonfunctional isoforms. Despite the general …

Osteoclasts are multinuclear cells that degrade bone under both physiological and
pathophysiological conditions. Osteoclasts are therefore a major target of osteoporosis …

Introduction A potential role for the orphan G protein-coupled receptor, GPR21, in linking
immune cell infiltration into tissues and obesity-induced insulin resistance has been …

Relaxin family peptide receptor 1 (RXFP1), the cognate receptor for relaxin, is a G-protein
coupled receptor (GPCR) possessing a unique extracellular region consisting of a domain of …