Hypertension is a leading contributor to cardiovascular mortality worldwide. Despite this, its
underlying mechanism (s) and the role of excess salt in cardiorenal dysfunction are unclear …

Hypertension and its comorbidities pose a major public health problem associated with
disease-associated factors related to a modern lifestyle, such high salt intake or obesity …

Epigenetic mechanisms may underlie the progression of diabetic kidney disease. Because
the kidney is a heterogeneous organ with different cell types, we investigated DNA …

Overactivation of the mineralocorticoid receptor signaling is implicated in cardiovascular
disease, including hypertensive heart disease. Oxidative stress is suggested to augment …

Experiments with hyperaldosteronemic animals suggest that, despite lowering plasma
aldosterone, salt worsens renal injury by paradoxical activation of the mineralocorticoid …

Aging is associated with a high prevalence of hypertension due to elevated susceptibility of
BP to dietary salt, but its mechanism is unknown. Serum levels of Klotho, an anti-aging …

There is increasing evidence for a crucial role of aberrant mineralocorticoid receptor (MR)
activation in heart failure, with clinical studies showing beneficial effects of MR blockade …

The progression of diabetic kidney disease (DKD), a leading cause of end-stage kidney
disease, involves mineralocorticoid receptor (MR) activation. We previously identified …

♦ Background Morphology changes of the peritoneal membrane after long-term peritoneal
dialysis (PD) consist of denudation of peritoneal mesothelial cells, interstitial sclerosis, and …

Maternal malnutrition, which causes prenatal exposure to excessive glucocorticoid, induces
adverse metabolic programming, leading to hypertension in offspring. In offspring of …