Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
Genome-wide association studies have identified common variants that only partially
explain the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from …
explain the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from …
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
Loss-of-function mutations protective against human disease provide in vivo validation of
therapeutic targets,,, but none have yet been described for type 2 diabetes (T2D). Through …
therapeutic targets,,, but none have yet been described for type 2 diabetes (T2D). Through …
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes
E Nilsson, PA Jansson, A Perfilyev, P Volkov… - Diabetes, 2014 - Am Diabetes Assoc
Genetics, epigenetics, and environment may together affect the susceptibility for type 2
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …
Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes
Low birthweight (LBW) individuals and offspring of women with gestational diabetes mellitus
(GDM) exhibit increased risk of developing type 2 diabetes (T2D) and associated …
(GDM) exhibit increased risk of developing type 2 diabetes (T2D) and associated …
[HTML][HTML] Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes
R Ribel-Madsen, MF Fraga, S Jacobsen… - PloS one, 2012 - journals.plos.org
Background Monozygotic twins discordant for type 2 diabetes constitute an ideal model to
study environmental contributions to type 2 diabetic traits. We aimed to examine whether …
study environmental contributions to type 2 diabetic traits. We aimed to examine whether …
[HTML][HTML] Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men
SC Jacobsen, C Brøns, J Bork-Jensen… - Diabetologia, 2012 - Springer
Aims/hypothesis Energy-dense diets that are high in fat are associated with a risk of
metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as …
metabolic diseases. The underlying molecular mechanisms could involve epigenetics, as …
[PDF][PDF] Associations of mitochondrial and nuclear mitochondrial variants and genes with seven metabolic traits
Mitochondria (MT), the major site of cellular energy production, are under dual genetic
control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA) …
control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA) …
Molecular and pharmacological characterization of insulin icodec: a new basal insulin analog designed for once-weekly dosing
E Nishimura, L Pridal, T Glendorf, BF Hansen… - BMJ Open Diabetes …, 2021 - drc.bmj.com
Introduction Insulin icodec is a novel, long-acting insulin analog designed to cover basal
insulin requirements with once-weekly subcutaneous administration. Here we describe the …
insulin requirements with once-weekly subcutaneous administration. Here we describe the …
[HTML][HTML] Young men with low birthweight exhibit decreased plasticity of genome-wide muscle DNA methylation by high-fat overfeeding
SC Jacobsen, L Gillberg, J Bork-Jensen… - Diabetologia, 2014 - Springer
Aims/hypothesis The association between low birthweight (LBW) and risk of developing type
2 diabetes may involve epigenetic mechanisms, with skeletal muscle being a prime target …
2 diabetes may involve epigenetic mechanisms, with skeletal muscle being a prime target …
Type 2 Diabetes Risk Alleles Near BCAR1 and in ANK1 Associate With Decreased β-Cell Function Whereas Risk Alleles Near ANKRD55 and GRB14 Associate …
MN Harder, R Ribel-Madsen… - The Journal of …, 2013 - academic.oup.com
Context: Recently, 10 novel type 2 diabetes (T2D) susceptibility single nucleotide
polymorphisms (SNPs) in ZMIZ1, ANK1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, BCAR1 …
polymorphisms (SNPs) in ZMIZ1, ANK1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, BCAR1 …