▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous
interest in the interaction between peripheral signals and brain targets involved in the …

The discovery of leptin in the mid-1990s has focused attention on the role of proteins
secreted by adipose tissue. Leptin has profound effects on appetite and energy balance …

Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

Diabetes mellitus is a chronic disease that leads to complications including heart disease,
stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target …

A TOTAL deficiency in or resistance to the protein leptin causes severe obesity1–4. As leptin
levels rise with increasing adiposity in rodents5 and man6, 7, it is proposed to act as a …

BACKGROUND & AIMS: The composition of the gut microbiome is affected by host
phenotype, genotype, immune function, and diet. Here, we used the phenotype of RELMβ …

Leptin, secreted by white adipocytes, has profound feeding, metabolic, and neuroendocrine
effects. Leptin acts on the brain, but the specific anatomic sites and pathways responsible for …

Mice, and cattle with mutations in the myostatin (GDF8) gene show a marked increase in
body weight and muscle mass, indicating that this new member of the TGF-β superfamily is a …

The association between obesity and diabetes supports an endocrine role for the adipocyte
in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte …

The fat-derived hormone, leptin, is proposed to serve as an adipostatic signal to the brain to
reduce food intake and body weight. In addition to its effects on body weight, chronic leptin …