Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

Y Kawamura, H Nakaoka, A Nakayama… - Annals of the …, 2019 - ard.bmj.com
Objective The first ever genome-wide association study (GWAS) of clinically defined gout
cases and asymptomatic hyperuricaemia (AHUA) controls was performed to identify novel …

[HTML][HTML] Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals

M Nakatochi, M Kanai, A Nakayama, A Hishida… - Communications …, 2019 - nature.com
Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we
investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese …

Study profile of the Japan multi-institutional collaborative cohort (J-MICC) study

K Takeuchi, M Naito, S Kawai, M Tsukamoto… - Journal of …, 2021 - jstage.jst.go.jp
ABSTRACT Background: The Japan Multi-institutional Collaborative Cohort (J-MICC) study
was launched in 2005 to examine gene–environment interactions in lifestyle-related …

Irregular sleep and all-cause mortality: a large prospective cohort study

C Omichi, T Koyama, H Kadotani, E Ozaki, S Tomida… - Sleep Health, 2022 - Elsevier
Objectives Previous studies using objective parameters have shown that irregular sleep is
associated with the disease incidence, progression, or mortality. This study aimed to …

[HTML][HTML] A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study

H Nakagawa-Senda, T Hachiya, A Shimizu… - Scientific reports, 2018 - nature.com
Coffee is one of the most widely consumed beverages worldwide, and its role in human
health has received much attention. Although genome-wide association studies (GWASs) …

Transgenic expression of human neutrophil peptide‐1 enhances hepatic fibrosis in mice fed a choline‐deficient, L‐amino acid–defined diet

R Ibusuki, H Uto, S Arima, S Mawatari… - Liver …, 2013 - Wiley Online Library
Background Neutrophils infiltrate the livers of patients with nonalcoholic steatohepatitis
(NASH). Human neutrophil peptides (HNP s) induce cytokine and chemokine production …

[HTML][HTML] Genomewide association study of leisure-time exercise behavior in Japanese adults

M Hara, T Hachiya, Y Sutoh, K Matsuo… - Medicine and science …, 2018 - ncbi.nlm.nih.gov
MEGUMI HARA1, TSUYOSHI HACHIYA2, YOICHI SUTOH2, KEITARO MATSUO3, 4,
YUICHIRO NISHIDA1, CHISATO SHIMANOE1, KEITARO TANAKA1, ATSUSHI SHIMIZU2 …

Sedentary time is associated with cardiometabolic diseases in a large Japanese population: a cross-sectional study

T Koyama, N Kuriyama, E Ozaki, S Tomida… - … of atherosclerosis and …, 2020 - jstage.jst.go.jp
Aim: Accumulating evidence reveals that sedentary behavior is associated with mortality and
cardiometabolic disease; however, there are potential age and sex differences in sedentary …

[HTML][HTML] Hypertension exacerbates liver injury and hepatic fibrosis induced by a choline-deficient L-amino acid-defined diet in rats

S Arima, H Uto, R Ibusuki… - International …, 2014 - spandidos-publications.com
The effect of hypertension on non-alcoholic fatty liver disease (NAFLD) remains unclear at
the molecular level. In this study, we investigated the effects of hypertension on the degree …

[HTML][HTML] Dietary fructose enhances the incidence of precancerous hepatocytes induced by administration of diethylnitrosamine in rat

R Kumamoto, H Uto, K Oda, R Ibusuki… - European journal of …, 2013 - Springer
Background Nonalcoholic fatty liver disease (NAFLD) is a risk for hepatocellular carcinoma
(HCC), but the association between a high-fructose diet and HCC is not fully understood. In …