cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2

US Jhala, G Canettieri, RA Screaton… - Genes & …, 2003 - genesdev.cshlp.org
The incretin hormone GLP1 promotes islet-cell survival via the second messenger cAMP.
Here we show that mice deficient in the activity of CREB, caused by expression of a …

Monogenic diabetes

A Bonnefond, R Unnikrishnan, A Doria… - Nature Reviews …, 2023 - nature.com
Monogenic diabetes includes several clinical conditions generally characterized by early-
onset diabetes, such as neonatal diabetes, maturity-onset diabetes of the young (MODY) …

Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map

E Bernal-Mizrachi, RN Kulkarni, DK Scott… - Diabetes, 2014 - Am Diabetes Assoc
Enhancing β-cell proliferation is a major goal for type 1 and type 2 diabetes research.
Unraveling the network of β-cell intracellular signaling pathways that promote β-cell …

[HTML][HTML] Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes

RN Kulkarni, JC Brüning, JN Winnay, C Postic… - Cell, 1999 - cell.com
Dysfunction of the pancreatic β cell is an important defect in the pathogenesis of type 2
diabetes, although its exact relationship to the insulin resistance is unclear. To determine …

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

YH Tseng, E Kokkotou, TJ Schulz, TL Huang… - Nature, 2008 - nature.com
Adipose tissue is central to the regulation of energy balance. Two functionally different types
of fat are present in mammals: white adipose tissue, the primary site of triglyceride storage …

[PDF][PDF] Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

MD Michael, RN Kulkarni, C Postic, SF Previs… - Molecular cell, 2000 - cell.com
The liver plays a central role in the control of glucose homeostasis and is subject to complex
regulation by substrates, insulin, and other hormones. To investigate the effect of the loss of …

TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

K Du, S Herzig, RN Kulkarni, M Montminy - Science, 2003 - science.org
Insulin resistance is a major hallmark in the development of type II diabetes, which is
characterized by the failure of insulin to promote glucose uptake in muscle and to suppress …

[HTML][HTML] Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

JE Gunton, RN Kulkarni, SH Yim, T Okada… - Cell, 2005 - cell.com
Summary β cell dysfunction is a central component of the pathogenesis of type 2 diabetes.
Using oligonucleotide microarrays and real-time PCR of pancreatic islets isolated from …

[HTML][HTML] Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

C Handschin, CS Choi, S Chin, S Kim… - The Journal of …, 2007 - Am Soc Clin Investig
The transcriptional coactivator PPARγ coactivator 1α (PGC-1α) is a strong activator of
mitochondrial biogenesis and oxidative metabolism. While expression of PGC-1α and many …

β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

RN Kulkarni, M Holzenberger, DQ Shih, U Ozcan… - Nature …, 2002 - nature.com
Regulation of glucose homeostasis by insulin depends on the maintenance of normal β-cell
mass and function. Insulin-like growth factor 1 (Igf1) has been implicated in islet …