[HTML][HTML] Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation

Y Tsutsumi, H Matsubara, H Masaki… - The Journal of …, 1999 - Am Soc Clin Investig
Angiotensin II (Ang II) is a potent vasopressor peptide that interacts with 2 major receptor
isoforms—AT1 and AT2. Although blood pressure is increased in AT2 knockout mice, the …

Expression of the Subtype 2 Angiotensin (AT2) Receptor Protein in Rat Kidney

R Ozono, ZQ Wang, AF Moore, T Inagami… - …, 1997 - Am Heart Assoc
In situ hybridization studies have suggested that the subtype 2 angiotensin (AT2) receptor
gene is expressed in fetal and newborn rat kidney but is undetectable in the adult animals …

Association of Helicobacter pyloriinfection with systemic inflammation and endothelial dysfunction in healthy male subjects

T Oshima, R Ozono, Y Yano, Y Oishi… - Journal of the American …, 2005 - jacc.org
Objectives: The goal of the present study was to determine whether seropositivity to
Helicobacter pylori (HP), Chlamydia pneumoniae (CP), and cytomegalovirus (CMV) is …

Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis

S Kurisu, R Ozono, T Oshima, M Kambe, T Ishida… - …, 2003 - Am Heart Assoc
We have previously demonstrated that stimulation of the angiotensin (Ang) II type 2 receptor
in vascular smooth muscle cells caused bradykinin production by activating kininogenase in …

Non-dipper phenomenon in essential hypertension is related to blunted nocturnal rise and fall of sympatho-vagal nervous activity and progress in retinopathy

Y Nakano, T Oshima, R Ozono, Y Higashi… - Autonomic …, 2001 - Elsevier
Although the relation between the blunted nocturnal decline in blood pressure and target
organ damages is well established, the mechanism underlying these results has not been …

Genetic ablation of the transcription repressor Bach1 leads to myocardial protection against ischemia/reperfusion in mice

Y Yano, R Ozono, Y Oishi, M Kambe… - Genes to …, 2006 - Wiley Online Library
Bach1 is a transcriptional repressor of heme oxygenase‐1 gene (Hmox‐1) and β‐globin
gene. Heme oxygenase (HO)‐1 is an inducible cytoprotective enzyme that degrades pro …

Effects of l-Arginine Infusion on Renal Hemodynamics in Patients With Mild Essential Hypertension

Y Higashi, T Oshima, R Ozono, M Watanabe… - …, 1995 - Am Heart Assoc
Previous studies have shown that endothelium-derived relaxing factor/nitric oxide plays an
important role in the regulation of systemic and renal hemodynamics. The purpose of the …

Myocardial protection against pressure overload in mice lacking Bach1, a transcriptional repressor of heme oxygenase-1

S Mito, R Ozono, T Oshima, Y Yano, Y Watari… - …, 2008 - Am Heart Assoc
Bach1 is a stress-responsive transcriptional factor that is thought to control the expression
levels of cytoprotective factors, including heme-oxygenase (HO)-1. In the present study, we …

Immunolocalization of Subtype 2 Angiotensin II (AT2) Receptor Protein in Rat Heart

ZQ Wang, AF Moore, R Ozono, HM Siragy… - Hypertension, 1998 - Am Heart Assoc
Angiotensin II exerts its effects on cardiovascular function and water and sodium
homeostasis by interacting with plasma membrane receptors on target organs. The …

Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling

Y Oishi, R Ozono, Y Yano, Y Teranishi, M Akishita… - …, 2003 - Am Heart Assoc
The aim of this study was to determine the role of the AT2 receptor (AT2R) in left ventricular
(LV) remodeling after myocardial infarction (MI). The left anterior descending arteries were …