[HTML][HTML] Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome

DP Macfarlane, S Forbes… - Journal of …, 2008 - joe.bioscientifica.com
Estrogen affects proliferation and migration of different skin components, thus influencing
wound healing processes. The human keratinocyte cell line NCTC 2544 has been used to …

Considerations and challenges of islet transplantation and future therapies on the horizon

S Walker, M Appari, S Forbes - American Journal of …, 2022 - journals.physiology.org
Islet transplantation is a treatment for selected adults with type 1 diabetes and severe
hypoglycemia. Islets from two or more donor pancreases, a scarce resource, are usually …

[HTML][HTML] Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial

C Chiswick, RM Reynolds, F Denison… - The lancet Diabetes & …, 2015 - thelancet.com
Background Maternal obesity is associated with increased birthweight, and obesity and
premature mortality in adult offspring. The mechanism by which maternal obesity leads to …

Effects of islet transplantation on microvascular and macrovascular complications in type 1 diabetes

L Reid, F Baxter, S Forbes - Diabetic Medicine, 2021 - Wiley Online Library
Type 1 diabetes is associated with high morbidity and mortality from microvascular and
macrovascular disease with considerable economic cost to society. Islet cell transplantation …

The impact of islet mass, number of transplants, and time between transplants on graft function in a national islet transplant program

S Forbes, AJ Flatt, D Bennett… - American Journal of …, 2022 - Wiley Online Library
The UK islet allotransplant program is nationally funded to deliver one or two transplants
over 12 months to individuals with type 1 diabetes and recurrent severe hypoglycemia …

[HTML][HTML] Validation of the BETA-2 score: an improved tool to estimate beta cell function after clinical islet transplantation using a single fasting blood sample

S Forbes, RA Oram, A Smith, A Lam, T Olateju… - American Journal of …, 2016 - Elsevier
The beta score, a composite measure of beta cell function after islet transplantation, has
limited sensitivity because of its categorical nature and requires a mixedmeal tolerance test …

Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism

AAR Thompson, RS Dickinson, F Murphy… - Science …, 2017 - science.org
Hypoxia and bacterial infection frequently coexist, in both acute and chronic clinical settings,
and typically result in adverse clinical outcomes. To ameliorate this morbidity, we …

Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery

LI Stirrat, JR O'Reilly, SM Barr, R Andrew… - …, 2016 - Elsevier
Background The maternal hypothalamic-pituitary-adrenal-axis (HPAA) undergoes dramatic
activation during pregnancy. Increased cortisol and corticotrophin-releasing-hormone (CRH) …

Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing β …

MJ Lima, KR Muir, HM Docherty, R Drummond… - Diabetes, 2013 - Am Diabetes Assoc
Because of the lack of tissue available for islet transplantation, new sources of β-cells have
been sought for the treatment of type 1 diabetes. The aim of this study was to determine …

Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre‐eclampsia

JJ Logie, FC Denison, SC Riley… - Clinical …, 2012 - Wiley Online Library
Objectives Circulating concentrations of the peptide kisspeptin have been proposed as a
novel biomarker for early detection of pre‐eclampsia. Our aims were to assess analytical …