In obese patients with type 2 diabetes, insulin delivery to and insulin-dependent glucose
uptake by skeletal muscle are delayed and impaired. The mechanisms underlying the delay …

Insulin resistance is often associated with impeded insulin signaling due either to decreased
concentrations or functional modifications of crucial signaling molecules including insulin …

Background Limited evidence suggests that multifactorial interventions for control of
glucose, blood pressure, and lipids reduce macrovascular complications and mortality in …

Insulin receptor substrate (Irs) mediates metabolic actions of insulin. Here, we show that
hepatic Irs1 and Irs2 function in a distinct manner in the regulation of glucose homeostasis …

In the management of diabetes mellitus, one of the most important goals is to prevent its
micro-and macrovascular complications, and to that end, multifactorial intervention is widely …

Aging is considered to be accelerated by insulin signaling in lower organisms, but it
remained unclear whether this could hold true for mammals. Here we show that mice with …

Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal
expansion (MCE) is a key step. Although this process is known to be regulated by cell cycle …

Hepatic insulin signalling involves insulin receptor substrates (Irs) 1/2, and is normally
associated with the inhibition of gluconeogenesis and activation of lipogenesis. In diabetes …

Sarcopenia is distinct from normal muscle atrophy in that it is closely related to a shift in the
muscle fiber type. Deficiency of the anabolic action of androgen on skeletal muscles is …

To evaluate the effect of multifactorial intervention on the onset and progression of diabetic
kidney disease in the patients with type 2 diabetes, we analyzed the effects of intensified …