Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating
binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we …

Fine structural details of glycans attached to the conserved N-glycosylation site significantly
not only affect function of individual immunoglobulin G (IgG) molecules but also mediate …

Objective Glycans attached to the Fc portion of IgG are important modulators of IgG effector
functions. Interindividual differences in IgG glycome composition are large and they …

Recovery after cardiac surgery is a complex process that has to compensate for both
individual variability and extensive tissue damage in the context of systemic inflammation …

Rising awareness of the universal importance of protein N-glycosylation governs the
development of further advances in N-glycan analysis. Nowadays it is well known that …

Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan
moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been …

Objective To determine the extent to which genetic and epigenetic factors contribute to
variations in glycosylation of immunoglobulin G (IgG) in humans. Methods 76 N-glycan traits …

Aims/hypothesis Better understanding of type 2 diabetes and its prevention is a pressing
need. Changes in human plasma N-glycome are associated with many diseases and …

Background Chronic obstructive pulmonary disease (COPD) is a complex condition, whose
diagnosis requires spirometric assessment. However, considering its heterogeneity …

Glycans constitute the most abundant and diverse form of the post-translational
modifications, and animal studies have suggested the involvement of IgG glycosylation in …