Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet

L Xu, N Nagata, G Chen, M Nagashimada… - BMJ Open Diabetes …, 2019 - drc.bmj.com
Objective We reported previously that empagliflozin—a sodium-glucose cotransporter
(SGLT) 2 inhibitor—exhibited preventive effects against obesity. However, it was difficult to …

Antibody-based receptor targeting using an Fc-binding peptide-dodecaborate conjugate and macropinocytosis induction for boron neutron capture therapy

I Nakase, A Aoki, Y Sakai, S Hirase, M Ishimura… - ACS …, 2020 - ACS Publications
Boron neutron capture therapy (BNCT) is a radiation method used for cancer therapy.
Cellular uptake of boron-10 (10B) atoms induces cancer cell death by the generation of …

[HTML][HTML] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo

M Funaki, J Kitabayashi, T Shimakami, N Nagata… - Scientific reports, 2017 - nature.com
Sphingosine-1-phospate is a potent bioactive lipid metabolite that regulates cancer
progression. Because sphingosine kinase 1 and sphingosine kinase 2 (SPHK 1/2) are both …

DPP-4 inhibition with anagliptin reduces lipotoxicity-induced insulin resistance and steatohepatitis in male mice

Y Sakai, G Chen, Y Ni, F Zhuge, L Xu, N Nagata… - …, 2020 - academic.oup.com
Excessive hepatic lipid accumulation drives the innate immune system and aggravates
insulin resistance, hepatic inflammation, and fibrogenesis, leading to nonalcoholic …

Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability

Y Sakai, H Arie, Y Ni, F Zhuge, L Xu… - Journal of …, 2020 - joe.bioscientifica.com
Intestinal mucosal barrier dysfunction is closely related to the pathogenesis of nonalcoholic
steatohepatitis (NASH). Gut immunity has been recently demonstrated to regulate gut barrier …

A mouse air pouch model for evaluating the immune response to Taenia crassiceps infection

EB Gaspar, YI Sakai, E De Gaspari - Experimental parasitology, 2014 - Elsevier
The experimental system of Taenia crassiceps cysticerci infection in BALB/c mice is
considered to be the most representative model of cysticercosis. In our work, mice were …

100% rapid rescreening for quality assurance in a quality control program in a public health cytologic laboratory

MG Mattosinho de Castro Ferraz, M Dall'Agnol… - Acta cytologica, 2005 - karger.com
Nov2005: 100% Rapid Rescreening for Quality Assurance in a Quality Control Program in a
Public Health Cytologic Laboratory Page 1 Objective To verify the efficacy of the quality control …

Morphometric evaluation of nucleolar organizer regions in cervical intraepithelial neoplasia

YI Sakai, AT Sakai, S Isotani, MJ Cavaliere… - … -Research and Practice, 2001 - Elsevier
The objective of this study was to determine whether some morphometric parameters and
two different methods of counting AgNOR dots were correlated with the grade of cervical …

SISCOLO-quality control system in the health public laboratories: preliminary study

MYS Maeda, C di Loreto, E Barreto… - Jornal Brasileiro de …, 2004 - SciELO Brasil
Analisar criticamente os primeiros resultados do Sistema de Informação Laboratorial do
Programa Nacional de Combate ao Câncer de Colo Uterino (SISCOLO-Qualidade). Foram …

[HTML][HTML] Estudo preliminar do SISCOLO-Qualidade na rede de saúde pública de São Paulo

MYS Maeda, C Di Loreto, E Barreto… - Jornal Brasileiro de …, 2004 - SciELO Brasil
Analisar criticamente os primeiros resultados do Sistema de Informação Laboratorial do
Programa Nacional de Combate ao Câncer de Colo Uterino (SISCOLO-Qualidade). Foram …