Genetics/genomes/proteomics/metabolomics

A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes: a prospective study in three independent cohorts

Karolina Tuomisto, Joonatan Palmu, Tao Long, Jeramie D Watrous, Kysha Mercader, Kim A Lagerborg, Allen Andres, Marko Salmi, Sirpa Jalkanen, Ramachandran S Vasan, Michael Inouye, Aki S Havulinna, Jaakko Tuomilehto, Pekka Jousilahti, Teemu J Niiranen, Susan Cheng, Mohit Jain, Veikko Salomaa

10.1136/bmjdrc-2021-002519

March 31, 2022

First trimester plasma microRNAs levels predict Matsuda Index-estimated insulin sensitivity between 24th and 29th week of pregnancy

Cécilia Légaré, Véronique Desgagné, Cédrik Poirier, Kathrine Thibeault, Frédérique White, Andrée-Anne Clément, Michelle S Scott, Pierre-Étienne Jacques, Patrice Perron, Renée Guérin, Marie-France Hivert, Luigi Bouchard

10.1136/bmjdrc-2021-002703

March 4, 2022

missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand

Emily M Russell, Jenna C Carlson, Mohanraj Krishnan, Nicola L Hawley, Guangyun Sun, Hong Cheng, Take Naseri, Muagututi‘a Sefuiva Reupena, Satupa‘itea Viali, John Tuitele, Tanya J Major, Iva Miljkovic, Tony R Merriman, Ranjan Deka, Daniel E Weeks, Stephen T McGarvey, Ryan L Minster

10.1136/bmjdrc-2021-002275

February 10, 2022

Human serum metabolomic analysis reveals progression for high blood pressure in type 2 diabetes mellitus

Yin Zhang, Heru Zhao, Bin Liu, Haiyang Shu, Lulu Zhang, Mei Bao, Wenjun Yi, Yong Tan, Xinyu Ji, Chi Zhang, Ning Zhao, Guoming Pang, Dan He, Yuexi Wang, Li Li, Jianfeng Yi, Cheng Lu

10.1136/bmjdrc-2021-002337

October 28, 2021

Plasma protein glycosylation is associated with cardiovascular disease, nephropathy, and retinopathy in type 2 diabetes

Elham Memarian, Leen M 't Hart, Roderick C Slieker, Roosmarijn F L Lemmers, Amber A van der Heijden, Femke Rutters, Giel Nijpels, Emma Schoep, Aloysius G Lieverse, Eric J G Sijbrands, Manfred Wuhrer, Mandy van Hoek, Viktoria Dotz

10.1136/bmjdrc-2021-002345

October 13, 2021

Genetic variants associated with beta-cell function and insulin sensitivity potentially influence bile acid metabolites and gestational diabetes mellitus in a Chinese population

Qiulun Zhou, Ying Wang, Yuqin Gu, Jing Li, Hui Wang, Junhong Leng, Weiqin Li, Zhijie Yu, Gang Hu, Ronald Ching Wan Ma, Zhong-Ze Fang, Xilin Yang, Guozhi Jiang

10.1136/bmjdrc-2021-002287

September 13, 2021

Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent

Danielle E Haslam, Liming Liang, Dong D Wang, Rachel S Kelly, Clemens Wittenbecher, Cynthia M Pérez, Marijulie Martínez, Chih-Hao Lee, Clary B Clish, David T W Wong, Laurence D Parnell, Chao-Qiang Lai, José M Ordovás, JoAnn E Manson, Frank B Hu, Meir J Stampfer, Katherine L Tucker, Kaumudi J Joshipura, Shilpa N Bhupathiraju

10.1136/bmjdrc-2021-002298

August 19, 2021

Identification of candidate gene variants of monogenic diabetes using targeted panel sequencing in early onset diabetes patients

Dong-Hwa Lee, Soo-Heon Kwak, Hee Sue Park, Eu Jeong Ku, Hyun Jeong Jeon, Tae Keun Oh

10.1136/bmjdrc-2021-002217

June 16, 2021

Serum galectin-3BP as a novel marker of obesity and metabolic syndrome in Chinese adolescents

Shihan Zhen, Yanan Ma, Yanshuo Han, Zhongyi Zhao, Xuelian Yang, Deliang Wen

10.1136/bmjdrc-2020-001894

April 28, 2021

Metabolites in the association between early-life famine exposure and type 2 diabetes in adulthood over a 5-year follow-up period

Yuying Wang, Fangzhen Xia, Heng Wan, Chi Chen, Yi Chen, Wen Zhang, Ningjian Wang, Yingli Lu

10.1136/bmjdrc-2020-001935

April 22, 2021