You are here

  • Home
  • Archive
  • Volume 7, Issue 1
  • Elevated serum adiponectin, elevated tumor necrosis factor-α and decreased transthyretin in Japanese elderly women with low grip strength and preserved insulin sensitivity

Article Text

Article menu

Download PDFPDF

XML
Metabolism
Elevated serum adiponectin, elevated tumor necrosis factor-α and decreased transthyretin in Japanese elderly women with low grip strength and preserved insulin sensitivity
  1. Mika Takeuchi1,
  2. Ayaka Tsuboi2,3,
  3. Satomi Minato2,4,
  4. Megumu Yano2,
  5. Kaori Kitaoka2,5,
  6. Miki Kurata1,2,
  7. Tsutomu Kazumi2,6,
  8. Keisuke Fukuo1,2
  1. 1Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan
  2. 2Research Institute for Nutrition Sciences, Mukogawa Women’s University, Nishinomiya, Japan
  3. 3Department of Nutrition, Osaka City Juso Hospital, Osaka, Japan
  4. 4Graduate School of Human Science and Environment, University of Hyogo, Himeji, Japan
  5. 5Department of Nutritional Sciences for Well-being, Faculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, Kashiwara, Osaka, Japan
  6. 6Diabetes Division, Department of Medicine, Kohnan Kakogawa Hospital, Kakogawa, Japan
  1. Correspondence to Dr Tsutomu Kazumi; kazumi{at}mukogawa-u.ac.jp

Abstract

Objective To determine if serum adiponectin levels are associated with low grip strength and/or low muscle mass in the elderly independently of insulin resistance and inflammation.

Research design and methods Cross-sectional associations were analyzed by logistic regression between low grip strength and/or low muscle mass and body composition, elevated serum adiponectin (≥20 mg/L), and biomarkers of nutrition status, insulin resistance and inflammation in 176 community-living Japanese elderly women. Sarcopenia was evaluated using the Asian criteria.

Results In bivariate analyses, low grip strength (n=71) was positively associated with age, log tumor necrosis factor-α and hyperadiponectinemia (n=34) and inversely with body weight, height, skeletal muscle mass, serum albumin, transthyretin (TTR), fat mass, serum zinc and hemoglobin (all p<0.01). In a fully adjusted model, TTR (OR 0.90; 95% CI 0.83 to 0.98, p=0.01) in addition to age (p=0.01), height (p<0.001) and skeletal muscle mass (p=0.018) emerged as independent determinants of low grip strength. Mean waist circumference and high-density lipoprotein cholesterol did not differ between women with and without low grip strength and were within the respective normal range. Although hyperadiponectinemia was a single metabolic correlate of low muscle mass (n=87), low serum cholesterol, albumin and TTR in addition to hyperadiponectinemia were associated with sarcopenia (n=45).

Conclusions Hyperadiponectinemia, elevated tumor necrosis factor-alpha and decreased TTR, a biomarker of age-related catabolic states, were found in community-living Japanese elderly women with low grip strength and preserved insulin sensitivity although hyperadiponectinemia was a single correlate of low muscle mass.

  • elderly women
  • grip strength
  • muscle mass
  • sarcopenia
  • adiponectin
  • transthyretin
  • insulin resistance
  • inflammation

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjdrc-2019-000675

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors MT, AT, SM, MY, KK and MK collected and analyzed data. TK wrote the manuscript and KF reviewed and edited it. All authors approved the final version of the manuscript to be published. TK supervised the study, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Ethics approval The Ethics Committees of the Mukogawa Women’s University (No. 11-7 on 20/5/2011).

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data availability statement No data are available.